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When Penny was a little lightheaded from the powerful pain medication and a muscle relaxer that the hospital gave her after she dislocated her shoulder from slipping in the bathtub, Penny asked Sheldon to sing "Soft Kitty" to her (according to her, "Injured and drugged is a kind of sick"). After much prompting, the two sing it as a round.
Sheldon sings the song to Professor Proton while the latter is in hospital.
